Yes—both hormone imbalance and, in some cases, hormone therapy can influence weight.

Common hormonal contributors to weight gain include:

• Declining estrogen in women
• Lower testosterone in men
• Thyroid dysfunction
• Elevated cortisol from chronic stress
• Insulin resistance and blood sugar imbalance

These shifts can affect metabolism, appetite, fat storage, and muscle mass.

Bioidentical hormone therapy itself does not inherently cause weight gain, but if dosing is not individualized—or if underlying factors such as thyroid or insulin resistance are not addressed—patients may notice changes in fluid retention or appetite.

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